When: Thursday 22 April 2010 at 0850 Ends: Thursday 22 April 2010 at 1630
Location: University of Oulu, Faculty of Medicine, lecture hall 101A, Address Aapistie 5A, Oulu, Finland
Oulu Symposium on Drug Metabolism: Xenobiotics - from evolution to medicines
Apr. 22nd University of Oulu, Faculty of Medicine, lecture hall 101A, Address Aapistie 5A, Oulu, Finland
The symposium is dedicated to Prof. Olavi Pelkonen in recognition of his achievements and contributions to the advancement of the research on drug metabolism.
PROGRAM Thursday 22.4.2010 Thursday 22.4.2010
8.50 – 9.00 Prof. Jukka Hakkola, University of Oulu: Opening words
Session 1 Evolution, Genetics and Regulation of Drug Metabolising Enzymes
Chairperson Dr. Moshe Finel, University of Helsinki
9.00 – 9.45 Prof. Magnus Ingelman-Sundberg, Karolinska Institutet, Stockholm, Sweden: Teleconference Evolution and genetics of cytochrome P450 enzymes
9.45 – 10.15 Prof. Paavo Honkakoski, University of Eastern Finland: Nuclear receptors as xenosensors
10.15 – 10.45 Prof. Matti Lang, National Research Centre for Environmental Toxicology, Brisbane, Australia: The unifying theory of gene expression; an integrated multistage process
10.45 – 11.15 Coffee break Session 2 Placental Metabolism and Transport
Chairperson Prof. Jukka Hakkola, University of Oulu
11.15 – 11.45 Prof. Markku Pasanen, University of Eastern Finland: Environmental chemical stress, maternal diseases and expression of human placental xenobiotic and steroid metabolizing enzymes
11.45 – 12.15 Prof. Kirsi Vähäkangas, University of Eastern Finland: Placental drug transporters in fetal exposure
12.15 – 13.15 Lunch Session 3 Role of Drug Metabolising Enzymes in Toxicology and Environment
Chairperson Prof. Arja Rautio, University of Oulu
13.15 – 13.45 Prof. Jorma Ahokas, RMIT University, Melbourne, Australia: Teleconference CYP in environmental toxicology
13.45 – 14.15 Prof. Hannu Raunio, University of Eastern Finland: Modelling of cytochrome P450 active site –CYP2A6 as an example
14.15 – 14.45 Coffee break Session 4 Drug metabolism in drug development and towards individualized therapy
Chairperson Dr. Miia Turpeinen, University of Oulu
14.45 – 15.15 Prof. Amin Rostami-Hodjegan, University of Manchester, Manchester, UK: Teleconference In vitro-in vivo extrapolation of ADME in Drug Development
15.15 – 15.45 Dr. Jarmo S. Salonen, Orion Corporation Orion Pharma, Finland: Species differences in metabolism: Impact on the development of imidazole drugs
15.45 – 16.15 Dr. Mikko Niemi, University of Helsinki: OATP transporter polymorphisms and drug treatment
Closing
16.30 – Business meeting of the Finnish Pharmacological Society
Forthcoming Events
Thursday 22 April 2010 at 0850 - Oulu Symposium on Drug Metabolism: Xenobiotics - from evolution to medicines